Systemic lupus erythematosus (SLE) presents with diverse clinical features causing diagnostic challenges. Apart from the clinical features, autoantibodies are important for diagnosis along with certain laboratory parameters. Diagnosis is made with the European League against Rheumatism/American College of Rheumatology 2019 Criteria. The case series presented here signifies the correlation between anti-dsDNA positivity and its association with poor prognosis and renal disease, whereas anti-double-stranded DNA (anti-dsDNA) negativity may lead to a lack of renal involvement and may be associated with polyserositis. The importance lies in the fact that these patients with anti-dsDNA negativity should be followed up for assessing conversion to positivity of anti-dsDNA, thus altering the prognosis and leading to renal involvement. Moreover, anti-SSA-positive SLE patients must be followed up for possible development of sicca symptoms.

Somnath Maitra graduated with an M.B.B.S. degree from Calcutta Medical College, Kolkata, under the University of Calcutta in 2004 and earned an M.D. in General Medicine from Calcutta National Medical College and Hospital (CNMCH), Kolkata, affiliated with The West Bengal University of Health Sciences, in 2010. With over 11 years of undergraduate teaching experience, Dr. Somnath Maitra has served as Senior Resident (SR), Resident Medical Officer (RMO), Assistant Professor, and Associate Professor in General Medicine. Currently, Dr.Somnath Maitra has been working as a Professor of Medicine since August 1, 2023. A recognized examiner for M.B.B.S. examinations under WBUHS and a postgraduate teacher in general medicine, Dr. Somnath Maitra has also completed CISP, Revised Basic Course Workshop, AETCOM training, and BCBR training. An accomplished academic, Dr. Somnath Maitra has 36 research papers published in nationally and internationally indexed journals and has co-authored the international book Updates in Dengue Fever (2014) along with contributing chapters such as "Warfarin Toxicity Management" (2012) and "Updates in Scrub Typhus" (2022). Selected as the editor of three peer-reviewed international journals, Dr. Somnath Maitra is a member of API and IAMCON and has been a speaker at the 3rd Annual Webinar on Orthopedics, Rheumatology, and Musculoskeletal Disorders in Dubai (December 2023). He was also honored with the Academic Excellence Award at PTWCON 2024.